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ea0081p59 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Impaired glucose homeostasis in a tau knock-in mouse model

Benderradji Hamza , Kraiem Sarra , Emilie Courty , Eddarkaoui Sabiha , Cyril Bourouh , Emilie Faivre , Laure Rolland , Emilie Caron , Melanie Besegher , Frederik Oger , Theo Boschetti , Kevin Carvalho , Bryan Thiroux , Thibaut Gauvrit , Emilie Nicolas , Victoria Gomez-Murcia , Anna Bogdanova , Antonino Bongiovanni , Anne Tailleux , Steve Lancel , Kadiombo Bantubungi , Nicolas Sergeant , Jean-Sebastien Annicotte , Luc Buee , Didier Vieau , David Blum , Valerie Buee-Scherrer

Introduction: Alzheimer disease (AD) is the leading cause of dementia. While impaired glucose homeostasis has been shown to increase AD risk and pathological loss of tau function, the latter has been suggested to contribute to the emergence of the glucose homeostasis alterations observed in AD patients. However, the links between tau impairments and glucose homeostasis, remains unclear.Objective: In order to better understand the links between tau and gl...

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ea0081p182 | Reproductive and Developmental Endocrinology | ECE2022

Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men highlights new potential physiological functions of AMH on FSH secretion and sperm motility

Benderradji Hamza , Anne-Laure Barbotin , Maryse Leroy-Billiard , Julie Prasivoravong , Francois Marcelli , Christine Decanter , Geoffroy Robin , Valerie Mitchell , Jean-Marc Rigot , Antonino Bongiovanni , Florent Sauve , Luc Buee , Claude-Alain Maurage , Maryse Cartigny , Arnauld Villers , Vincent Prevot , Sophie Catteau-Jonard , Nicolas Sergeant , Paolo Giacobini , Pascal Pigny , Clara Leroy

Background: Few studies to date have attempted to measure serum anti-Müllerian hormone (AMH) levels in adult men, and solid references ranges have not yet been defined on a large cohort.Objective: In this study, we aimed to first establish the reference ranges for serum AMH and AMH-to-total testosterone ratio (AMH/tT) in adult males. Secondly, we investigated the relationship between serum AMH and both reproductive hormones and semen parameters....

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Endocrine Abstracts

Impaired glucose homeostasis in a tau knock-in mouse model

Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men highlights new potential physiological functions of AMH on FSH secretion and sperm motility

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